Primary uveal lymphoma effectively managed with oral chlorambucil: a case report
نویسندگان
چکیده
INTRODUCTION Ocular lymphomas account for five to 10 percent of all extra-nodal lymphomas. Primary uveal lymphoma is quite a rare entity and usually unilateral. We present a case of a primary uveal lymphoma with conjunctival and orbital extension, successfully managed with oral chlorambucil. CASE PRESENTATION A 71-year-old Caucasian man presented to our facility with visual loss in his only functioning eye (left). On clinical examination, we found a conjunctival lesion with a choroidal infiltration and a secondary retinal detachment. Ultrasound and magnetic resonance imaging studies revealed a choroidal tumour mass and two other lesions around the optic nerve. Results from an incisional biopsy revealed a low-grade B-cell lymphoma (CD20+, CD43+, bcl2+, CD3-). A diagnosis of primary uveal lymphoma was made. Our patient was started on a chemotherapy regime with no effect, and then oral chlorambucil was administered, with a relatively good result. At 10 months after the start of chlorambucil treatment, a best-corrected visual acuity of 0.4 was recorded, the choroidal mass had practically disappeared and the extra-ocular lesions had shrunk. CONCLUSIONS In all, 61 to 80 cases of primary uveal lymphoma have already been described in the literature. Generally, it is an indolent tumor with a good prognosis. However, there are some reports of aggressive tumor behavior a few years after initial diagnosis (about eight percent of cases). Other treatment options are orbital irradiation at low doses (20 to 40 Gy) or steroid administration. This is the first documented report of the efficacy of oral chlorambucil in the treatment of primary uveal lymphoma.
منابع مشابه
Multifocal Primary Non- Hodgkin’s Lymphoma of the Oral Cavity: Report of Three Cases and Review of the Literature
Objective: Oral non- Hodgkin’s lymphoma (NHL) is a relatively rare neoplasm that may develop in the soft tissues or jaw bones, with or without node or marrow involvement. Oral lymphomas are often difficult to diagnose as there are no characteristic clinical features and usually appear as non-tender swellings. Case: We describe clinical, radiographic, histopathological and immunohistochemica...
متن کاملCentral Mucoepidermoid Carcinoma with Non-Hodgkin Lymphoma: A Case Report
Introduction: Central mucoepidermoid carcinoma (CMEC) is a rare primary intraosseous bony lesion. The mandible is more commonly affected than the maxilla. CMEC is frequently misdiagnosed radiographically and clinically as a benign odontogenic tumor or cyst. Case Presentation: We present a rare case with a secondary malignant neoplasm. A male patient was initially diagnosed with B-cell non-Hodg...
متن کاملPrimary cutaneous CD30+T cell lymphoma: A case report
Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T cell lymphoma on his face, which presented as an ulcerated nodule.
متن کاملT-Cell Lymphoma of Palate with Nose and Maxillary Sinus Involvement: A Case Report
Oral cavity T-cell lymphoma occurs rarely. This case report describes a patient with such a tumor. The case was a 75 years old man presented with a painless swelling on his hard palate mucosa. He had suffered from nose- bleeding and nasal obstruction. Pathology revealed the presence of a T-cell lymphoma tumor in the palate. Though rare, the signs and symptoms of the case suggest that T-cell lym...
متن کاملExtranodal Non-Hodgkin’s Lymphoma of the Oral Cavity: A Case Report
Lymphomas are solid malignant tumors having a wide spectrum of clinical and pathological features. Non-Hodgkin’s lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extranodal sites, including the gastro intestinal tract, Waldeyer’s ring, bone, skin, and brain. Intraoral non-Hodg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013